Infographic: Slow-release dexamethasone in proliferative vitreoretinopathy (PVR)
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چکیده
منابع مشابه
Ozurdex® (a slow-release dexamethasone implant) in proliferative vitreoretinopathy: study protocol for a randomised controlled trial
BACKGROUND Proliferative vitreoretinopathy (PVR) is the commonest cause of late anatomical failure in rhegmatogenous retinal detachment. Visual and anatomical outcomes remain poor despite advances in vitreoretinal surgical techniques with reported primary failure rates of up to nearly 50%. Numerous adjunctive medications have been evaluated in clinical trials with no agent gaining widespread ac...
متن کاملRelaxing retinotomies and retinectomies in the management of retinal detachment with severe proliferative vitreoretinopathy (PVR)
UNLABELLED Relaxing retinotomies and retinectomies are used in the presence of retinal shortening resulting from retinal incarceration or fibrous proliferation and contraction that prevents contact of the retina with the retinal pigment epithelium. The peripheral retina is usually cut or excised to preserve function of the posterior retina which is more visually significant. OBJECTIVE To inve...
متن کاملExperimental model of proliferative vitreoretinopathy (PVR) in the vitrectomised eye: effect of silicone oil.
Silicone oil alone or as an adjunct to vitrectomy is widely used for the treatment of retinal detachment complicated by proliferative vitreoretinopathy (PVR). It appears to reduce the tendency for recurrent traction detachment, but the mechanism of this action is obscure. We have studied the effects of silicone oil in an experimental animal model. Twenty five thousand homologous fibroblasts wer...
متن کاملProliferative vitreoretinopathy.
PURPOSE. The migration, proliferation, differentiation, and adhesion of cells and other cellular functions are influenced by the surrounding extracellular matrix, in normal and wound-healing conditions. The matrix metalloproteinases (MMPs) are a family of enzymes that degrade and remodel the extracellular matrix and, thus, play a central role in the wound-healing process. Proliferative vitreore...
متن کاملApoptosis in proliferative vitreoretinopathy.
PURPOSE To study the involvement of apoptosis using different apoptosis markers in PVR pathogenesis. METHODS The presence of mRNA coding for Fas, Fas ligand (FasL), and TNF-related apoptosis inducing ligand (TRAIL) was investigated in vitreous samples from 46 consecutive patients-25 with PVR, 11 with retinal detachment (RD) not complicated by PVR, and 10 with macular hole (MH)-using RT-PCR. F...
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ژورنال
عنوان ژورنال: Eye
سال: 2021
ISSN: 0950-222X,1476-5454
DOI: 10.1038/s41433-021-01532-y